#创新药

Hengrui Pharmaceuticals: A Fortress Innovation Platform, But RMB 50 Already Pays for the Upgrade

Hengrui Pharmaceuticals is China's largest listed innovative-drug platform, still earning mainly from domestic drug sales while its valuation increasingly rests on converting self-funded R&D into commercial franchises and recurring overseas licensing income. 2025 revenue reached RMB 31.63 billion with net profit of RMB 7.71 billion and a fortress balance sheet holding RMB 40.16 billion of cash, yet at RMB 50.04 (about 41x trailing earnings) the price sits above the conservative fair value and leaves no margin of safety. Rating Hold: a rare high-quality China pharma platform already priced for an innovation-monetization upgrade it has not yet fully earned.

RemeGen: Two Self-Developed Drug Franchises and an Export Licensing Engine, With the A-Share Already Pricing a Cleaner Future Than the Filings Justify

RemeGen is a commercializing China innovative-biopharma with two self-developed franchises — telitacicept in autoimmune disease and disitamab vedotin in ADC oncology — plus an ex-China licensing engine (Vor Bio, Santen, AbbVie) that has become part of the business model. 2025 product sales reached CNY 2.31bn (up 35.8%) and reported profit turned positive at CNY 709.7m, but operating cash flow was only CNY 52.3m (about 0.07x conversion), Q1 2026 profit after non-recurring items stayed negative, and the A-share trades at roughly a 96.5% premium to the H-share — above even the optimistic per-share value. Rating Avoid: a good company at the wrong price on the Shanghai line, where an entry needs both a lower A-share price (CNY 36-40) and proof that recurring earnings quality has caught up to the approvals.

Kelun-Biotech: A Commercializing China ADC Franchise Priced for Much of Its sac-TMT and MSD Global Success

Kelun-Biotech is a commercial-stage China ADC developer whose equity value is dominated by its sac-TMT (TROP2) franchise in Greater China plus ex-China royalty economics from MSD. In 2025 product sales inflected to RMB542.7m within RMB2.06bn total revenue and the balance sheet held RMB4.56bn cash with no borrowings, yet the company still posted a RMB382.0m net loss as nearly all equity value concentrates in one molecule. Rating Hold: a real ADC franchise is forming, but at HK$419 the stock already prices in much of the sac-TMT China plus MSD global success path and offers no margin of safety.

Akeso, Inc.: A Commercial-Stage Antibody Innovator Still Priced on Ivonescimab's Global Option Value

Akeso is a commercial-stage Chinese antibody innovator with seven marketed products and record 2025 commercial sales of RMB3.03 billion, anchored by cadonilimab and ivonescimab. Yet the stock trades as a referendum on one molecule: whether ivonescimab's strong China data (a HARMONi-6 overall-survival win, HR 0.66) can survive global regulators, while 2025 operating cash flow stayed negative at RMB947.6 million and the shares fetch about 22x trailing sales. Rating Hold: rare science and a real China franchise, but the price still pre-pays too much of ivonescimab's ex-China upside; the ideal buy zone is HK$58-64.

阿斯利康 AstraZeneca 深度研究

阿斯利康是以肿瘤与罕见病为核心、靠研发与全球商业化变现的创新药巨头。2025 年收入 587.39 亿美元，增长重心向肿瘤（同比 +20%）与罕见病（+19%）集中、对冲 CVRM 老药承压，多平台结构比单引擎同业更均衡。研报评级持有：现价 178.75 美元对保守内在价值仍有溢价、安全边际不明显，高质量但已进入兑现压力期。

诺华(NVS) 横纵研报

诺华是瑞士巴塞尔总部的全球十大创新药企之一，2023 年 10 月剥离仿制药/生物类似药子公司 Sandoz 后转型为"纯创新药"pureplay，治疗管线覆盖心血管（Entresto）、肿瘤（Pluvicto/Kisqali）、免疫（Cosentyx）、神经（Kesimpta）、罕见病（Leqvio）；2025 财年营收 ~566 亿美元、营业利润率 30%、自由现金流 ~150 亿美元、股息连涨 28 年；当前最大挑战是 Entresto 心衰药 2025 年第四季度美国进入仿制药竞争。

递归制药（Recursion）横纵框架深度研究

递归制药（RXRX.US）是 AI 药物发现的旗帜标的——全球范围最大、整合最广的「AI-native」药企（2024 年合并 Exscientia 补齐精准化学），与英伟达、罗氏/基因泰克、拜耳、赛诺菲等深度合作，是「AI 制药平台 + 自研 biotech 管线」的混合体。收入 100% 来自块状、不可预测的合作里程碑，无任何产品收入；头号战略背书方英伟达已于 2025 年底清仓全部持股，创始人 CEO Chris Gibson 也已卸任。

天辰生物-B 横纵分析研究

中国 18A 创新药新股，核心抗 IgE 抗体 LP-003 临近 BLA；截至 2026-06-03 尚未上市交易，招股价 96.06 港元已计入不少成功预期、较保守内在价值 67.4 港元明显溢价。零收入零利润、价值高度集中 LP-003。理想买入 ≤54 港元。

Johnson & Johnson 深度价值分析：好公司不便宜

JNJ 是一家可理解、护城河深、自由现金流稳定的医疗龙头，但 234 美元的价格已接近模型乐观情景上沿、安全边际不足；现金回报率 3.4% 低于 10 年美债 4.57%，新买家更应等待。

Insmed 深度价值投资研究报告

好公司、贵价格。ARIKAYCE 与 BRINSUPRI 是稀缺呼吸专科资产，但当前约 109.5 美元已计入多重成功，owner earnings 仍为负、安全边际不足，合理买入区间 55–70 美元。

AbbVie 长期企业所有者视角深度研究

已走出 Humira 专利悬崖，Skyrizi/Rinvoq 双核接力（2025 年合计约占收入 42%），现金流强、分红扎实；当前 212.30 美元安全边际不足、账面负权益，评级观察，理想买入区 155-180 美元。

Alnylam Pharmaceuticals 深度价值投资分析

RNAi 创新药公司，2025 年首次全年盈利、AMVUTTRA 驱动放量；但收入高度集中、SBC 与融资结构复杂，约 299 美元缺乏安全边际，理想买入 200-240 美元。